Kyle Murphy

Research & Teaching Fellow

Contact Information

  • kmurphy5@unca.edu
  • 828-350-4570
  • 136 Zeis Hall

Office Hours

  • Tuesday 10:30 am - 12:00 pm
  • Wednesday 2:30 pm - 4:00 pm
  • Note: And by appointment. Online (see Moodle for link)

I grew up in the small town of Assonet, Massachusetts and graduated summa cum laude with my BS in chemistry (with a dual concentration in professional and also environmental chemistry) from Bridgewater State University (BSU) in 2014. BSU is a primarily undergraduate and liberal arts institution where I incorporated green chemistry research in improving existing syntheses for small-molecule enzyme inhibitors under Professor Edward Brush. Then, I attended graduate school at the University of Vermont (UVM) under Professor Severin Schneebeli where I primarily focused on the synthesis and materials investigation of conjugated freeform helical polymers. I graduated with my PhD in organic chemistry from UVM in 2019 and moved weeks later to Asheville to begin my postdoctoral research and teaching fellowship in Professor Amanda Wolfe’s lab. My current research focuses on synthesizing and subsequent biological testing of derivatives of known antibiotic empetroxepin to improve its antibacterial activity. In my free time I enjoy trail running, creative writing, and playing Dungeons & Dragons.

Education

  • Ph.D. University of Vermont
  • B.S. Bridgewater State University

Courses Taught

  • CHEM 111 General Chemistry Laboratory
  • CHEM 222 Organic Chemistry Laboratory
  • CHEM 231 Organic Chemistry

Selected Publications

K. E. Murphy, G. F. Sloan, G. V. Lawhern, G. E. Volk, J. T. Schumate, A. L. Wolfe. “Advances in antibiotic drug discovery: Reducing the barriers for antibiotic development” Future Medicinal Chemistry 2020, 12(22), 2067-2087.

M. Sharafi, J. P. Campbell, K. E. Murphy, R. O. Brown, S. T. Schneebeli. “Chiral auxiliaries for stereoselective electrophilic aromatic substitutions” Synlett (Synpacts) 2020, 32(03), 229-234.

M. Sharafi, K. T. McKay, M. Ivancic, D. R. McCarthy, N. Dudkina, K. E. Murphy, S. C. Rajappan, J. P. Campbell, Y. Shen, A. R. Badireddy, J. Li, S. T. Schneebeli. “Size-selective catalytic polymer acylation with a molecular tetrahedron” Chem (Cell Press) 2020, 6, 1469-1494.

J. P. Campbell, M. Sharafi, K. E. Murphy, J. L. Bocanegra, S. T. Schneebeli. “Precise molecular shape control of linear and branched strips with chirality-assisted synthesis” Supramol. Chem. 2019, 80, 565-574.

K. E. Murphy, J. L. Bocanegra, X. Liu, H.-Y. K. Chau, P. C. Lee, J. Li, S. T. Schneebeli. “Precise through space control of an abiotic electrophilic aromatic substitution reaction” Nature Commun. 2017, 8, 14840.